Publications

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies. Ward EL, Benowitz L, Brunner TM, Bu G, Cayouette M, Canto-Soler V, Dá Mesquita S, Di Polo A, DiAntonio A, Duan X, Goldberg JL, He Z, Hu Y, Liddelow SA, La Torre A, Margeta M, Quintana F, Shekhar K, Stevens B, Temple S, Venkatesh H, Welsbie D, Flanagan JG. Mol Neurodegener. 2025 Oct 14;20(1):108. PMID: 41088409

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration. Cueva Vargas JL, Belforte N, Vidal-Paredes IA, Dotigny F, Vande Velde C, Quintero H, Di Polo A. Mol Ther. 2025 Sep 23:S1525-0016(25)00766-X. PMID: 40994007

Pericytes in the optic nerve head. Waxman S, Villafranca-Baughman D, Phillippi J, Jakobs TC, Alarcon-Martinez L, Di Polo A, Sigal IA. Prog Retin Eye Res. 2025 Jul;107:101375. PMID: 40449651

Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation. Shiga Y, Rangel Olguin AG, El Hajji S, Belforte N, Quintero H, Dotigny F, Alarcon-Martinez L, Krishnaswamy A, Di Polo A. Cell Rep Med. 2024 Dec 17;5(12):101839. PMID: 39615485; PMCID: PMC11722116

Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction. Huang KC, Gomes C, Shiga Y, Belforte N, VanderWall KB, Lavekar SS, Fligor CM, Harkin J, Hetzer SM, Patil SV, Di Polo A, Meyer JS. Acta Neuropathol Commun. 2024 Oct 18;12(1):164. PMID: 39425218; PMCID: PMC11487784

Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma. El Hajji S, Shiga Y, Belforte N, Solorio YC, Tastet O, D’Onofrio P, Dotigny F, Prat A, Arbour N, Fortune B, Di Polo A. Sci Adv. 2024 Aug 9;10(32):eadl5722. PMID: 39110798; PMCID: PMC11305393

The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Johnson TV, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Zack DJ. Ophthalmol Sci. 2023 Aug 25;3(4):100390. PMID: 38025164; PMCID: PMC10630665

Optical coherence tomography and optical coherence tomography angiography: essential tools for detecting glaucoma and disease progression. Shiga Y, Nishida T, Jeoung JW, Di Polo A, Fortune B. Front Ophthalmol (Lausanne). 2023;3:1217125. PMID: 37982032; PMCID: PMC10655832

Neurovascular dysfunction in glaucoma. Alarcon-Martinez L, Shiga Y, Villafranca-Baughman D, Cueva Vargas JL, Vidal Paredes IA, Quintero H, Fortune B, Danesh-Meyer H, Di Polo A. Prog Retin Eye Res. 2023 Nov;97:101217. PMID: 37778617

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J; RReSTORe Consortium; Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. Mol Neurodegener. 2023 Sep 21;18(1):64. PMID: 37735444; PMCID: PMC10514988

Utility of light-adapted full-field electroretinogram ON and OFF responses for detecting glaucomatous functional damage. Dunn M, Cull G, Reynaud J, Jennings D, Holthausen T, Di Polo A, Fortune B. Transl Vis Sci Technol. 2023 Aug 1;12(8):16. PMID: 37594448; PMCID: PMC10445177

Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering. Tribble JR, Hui F, Quintero H, El Hajji S, Bell K, Di Polo A, Williams PA. Mol Aspects Med. 2023 Aug;92:101193. PMID: 37331129

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases. Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Mol Neurodegener. 2022 Nov 1;17(1):69. PMID: 36316783; PMCID: PMC9623952

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases. Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Mol Neurodegener. 2022 Oct 31;17(1):68. PMID: 36310167; PMCID: PMC9620636 Flores Molina M, Abdelnabi MN, Mazouz S, Villafranca-Baughman D, Trinh VQ, Muhammad S, Bédard N, Osorio Laverde D, Hassan GS, Di Polo A, Shoukry NH. Front Immunol. 2022 Sep 30;13:994480. PMID: 36248843; PMCID: PMC9562324

Neuroprotection, neuroenhancement, and neuroregeneration of the retina and optic nerve. Johnson TV, Di Polo A, Sahel JA, Schuman JS. Ophthalmol Sci. 2022 Sep 5;2(3):100216. PMID: 36245765; PMCID: PMC9559091

Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function. Quintero H, Shiga Y, Belforte N, Alarcon-Martinez L, El Hajji S, Villafranca-Baughman D, Dotigny F, Di Polo A. Cell Rep. 2022 Sep 13;40(11):111324. PMID: 36103832

Solving neurodegeneration: common mechanisms and strategies for new treatments. Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. Mol Neurodegener. 2022 Mar 21;17(1):23. PMID: 35313950; PMCID: PMC8935795

Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma. Alarcon-Martinez L, Shiga Y, Villafranca-Baughman D, Belforte N, Quintero H, Dotigny F, Cueva Vargas JL, Di Polo A. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2110329119. PMID: 35135877; PMCID: PMC8851476

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma. Belforte N, Agostinone J, Alarcon-Martinez L, Villafranca-Baughman D, Dotigny F, Cueva Vargas JL, Di Polo A. Mol Neurodegener. 2021 Jun 29;16(1):43. PMID: 34187514; PMCID: PMC8243567

Perspectives for preclinical mouse models of glaucoma after Boston keratoprosthesis type 1. Geoffrion D, Robert MC, Chodosh J, Di Polo A, Harissi-Dagher M. Exp Eye Res. 2021 Jul;208:108615. PMID: 33971222

Tear film cytokine profile of patients with the Boston Keratoprosthesis Type 1: comparing patients with and without glaucoma. Geoffrion D, Robert MC, Di Polo A, Koenekoop RK, Agoumi Y, Harissi-Dagher M. Invest Ophthalmol Vis Sci. 2021 Apr 1;62(4):20. PMID: 33856415; PMCID: PMC8054627

Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells. Korecki AJ, Cueva-Vargas JL, Fornes O, Agostinone J, Farkas RA, Hickmott JW, Lam SL, Mathelier A, Zhou M, Wasserman WW, Di Polo A, Simpson EM. Gene Ther. 2021 Jun;28(6):351-372. PMID: 33531684; PMCID: PMC8222000

Interpericyte tunnelling nanotubes regulate neurovascular coupling. Alarcon-Martinez L, Villafranca-Baughman D, Quintero H, Kacerovsky JB, Dotigny F, Murai KK, Prat A, Drapeau P, Di Polo A. Nature. 2020 Sep;585(7823):91-95. PMID: 32788726

Sex-specific differences in motor-unit remodeling in a mouse model of ALS. Martineau É, Di Polo A, Vande Velde C, Robitaille R. eNeuro. 2020 Feb 26;7(1):ENEURO.0388-19.2020. PMID: 32033983; PMCID: PMC7044502

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion. Alarcon-Martinez L, Yilmaz-Ozcan S, Yemisci M, Schallek J, Kılıç K, Villafranca-Baughman D, Can A, Di Polo A, Dalkara T. Acta Neuropathol Commun. 2019 Aug 20;7(1):134. PMID: 31429795; PMCID: PMC6701129

An antagonistic axon-dendrite interplay enables efficient neuronal repair in the adult zebrafish central nervous system. Beckers A, Van Dyck A, Bollaerts I, Van Houcke J, Lefevere E, Andries L, Agostinone J, Van Hove I, Di Polo A, Lemmens K, Moons L. Mol Neurobiol. 2019 May;56(5):3175-3192. PMID: 30105671

New MiniPromoter Ple345 (NEFL) drives strong and specific expression in retinal ganglion cells of mouse and primate retina. Simpson EM, Korecki AJ, Fornes O, McGill TJ, Cueva-Vargas JL, Agostinone J, Farkas RA, Hickmott JW, Lam SL, Mathelier A, Renner LM, Stoddard J, Zhou M, Di Polo A, Neuringer M, Wasserman WW. Hum Gene Ther. 2019 Mar;30(3):257-272. PMID: 30062914; PMCID: PMC6437624

Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS. Martineau É, Di Polo A, Vande Velde C, Robitaille R. Elife. 2018 Oct 15;7:e41973. PMID: 30320556; PMCID: PMC6234026

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Agostinone J, Alarcon-Martinez L, Gamlin C, Yu WQ, Wong ROL, Di Polo A. Brain. 2018 Jul 1;141(7):1963-1980. PMID: 29931057; PMCID: PMC6022605

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. Alarcon-Martinez L, Yilmaz-Ozcan S, Yemisci M, Schallek J, Kılıç K, Can A, Di Polo A, Dalkara T. Elife. 2018 Mar 21;7:e34861. PMID: 29561727; PMCID: PMC5862523

Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies. Ito YA, Di Polo A. Mitochondrion. 2017 Sep;36:186-192. PMID: 28866056

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease. Chiasseu M, Alarcon-Martinez L, Belforte N, Quintero H, Dotigny F, Destroismaisons L, Vande Velde C, Panayi F, Louis C, Di Polo A. Mol Neurodegener. 2017 Aug 3;12(1):58. PMID: 28774322

Neuroinflammation in glaucoma: A new opportunity. Williams PA, Marsh-Armstrong N, Howell GR; Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants. Exp Eye Res. 2017 Apr;157:20–27. PMID: 28242160

Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma. Chiasseu M, Cueva Vargas JL, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A. J Neurosci. 2016, 36(21):5785-5798. PMID: 27225768

The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Cueva Vargas JL, Belforte N, Di Polo A. Neurobiol Dis. 2016, 93:156-171. PMID: 27163643

Neuroinflammation in glaucoma: soluble tumor necrosis factor alpha and the connection with excitotoxic damage. Vargas JL, Di Polo A. Neural Regen Res. 2016, 11(3):424-426. PMID: 27127480

A magnetic microbead occlusion model to induce ocular hypertension-dependent glaucoma in mice. Ito YA, Belforte N, Cueva Vargas JL, Di Polo A. J Vis Exp. 2016, (109):e53731. PMID: 27077732

Retinal ganglion cell dendrite pathology and synapse loss: implications for glaucoma. Agostinone J, Di Polo A. Prog Brain Res. 2015, 220:199-216. PMID: 26497792

Soluble Tumor Necrosis Factor Alpha promotes retinal ganglion cell death in glaucoma via calcium-permeable AMPA receptor activation. Cueva Vargas JL, Osswald IK, Unsain N, Aurousseau MR, Barker PA, Bowie D, Di Polo A. J Neurosci. 2015, 35(35):12088-12102. PMID: 26338321

Dendrite pathology and neurodegeneration: focus on mTOR. Di Polo A. Neural Regen Res. 2015, 10(4):559-561. PMID: 2617081

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury. Morquette B, Morquette P, Agostinone J, Feinstein E, McKinney RA, Kolta A, Di Polo A. Cell Death Differ. 2015, 22(4):612-625. PMID: 25257176

Development of a cell permeable competitive antagonist of RhoA and CRMP4 binding, TAT-C4RIP, to promote neurite outgrowth. Khazaei MR, Montcalm S, Di Polo A, Fournier AE, Durocher Y, Tone SO. J Mol Neurosci. 2015, 55(2):406-415. PMID: 25015230

Drug and gene delivery to the back of the eye: from bench to bedside. Rowe-Rendleman CL, Durazo SA, Kompella UB, Rittenhouse KD, Di Polo A, Weiner AL, Grossniklaus HE, Naash MI, Lewin AS, Horsager A, Edelhauser HF. Invest Ophthalmol Vis Sci. 2014, 55(4):2714-2730. PMID: 24777644

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury. Wilson AM, Chiodo VA, Boye SL, Brecha NC, Hauswirth WW, Di Polo A. PLoS One. 2014, 9(4):e94175. PMID: 24714389

The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy. Slusar JE, Cairns EA, Szczesniak AM, Bradshaw HB, Di Polo A, Kelly ME. Neuropharmacology. 2013, 72:116-25. PMID: 23643752

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma. Almasieh M, MacIntyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Invest Ophthalmol Vis Sci. 2013, 54(5):3171-83. PMID: 23599333

ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. Wilson AM, Morquette B, Abdouh M, Unsain N, Barker PA, Feinstein E, Bernier G, Di Polo A. J Neurosci. 2013, 33(5):2205-16. PMID: 23365256

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice. Fukui H, Wong HT, Beyer LA, Case BG, Swiderski DL, Di Polo A, Ryan AF, Raphael Y. Sci Rep. 2012, 2:838. PMID: 23150788

The molecular basis of retinal ganglion cell death in glaucoma. Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. Prog Retin Eye Res. 2012, 31(2):152-81. PMID: 22155051

Gene therapy for retinal ganglion cell neuroprotection in glaucoma. Wilson AM, Di Polo A. Gene Ther. 2012, 19(2):127-36. PMID: 21975466

Current prospects in optic nerve protection and regeneration: sixth ARVO/Pfizer Ophthalmics Research Institute conference. Limb GA, Martin KR, Di Polo, A., et al. Sixth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Invest Ophthalmol Vis Sci. 2011, 52(8):5941-54. PMID: 21804096

A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1/2 pathway. Almasieh M, Lieven CJ, Levin LA, Di Polo A. J Neurochem. 2011, 118(6):1075-86. PMID: 21749374

Ocular neuroprotection by siRNA targeting caspase-2. Ahmed Z, Kalinski H, Berry M, Almasieh M, Ashush H, Slager N, Brafman A, Spivak I, Prasad N, Mett I, Shalom E, Alpert E, Di Polo A, Feinstein E, Logan A. Cell Death Dis. 2011, 2:e173. PMID: 21677688

Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Almasieh M, Zhou Y, Kelly ME, Casanova C, Di Polo A. Cell Death Dis. 2010, 1:e27. PMID: 21364635

ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, Di Polo A, Barker PA. Proc Natl Acad Sci U S A. 2010, 107(8):3817-22. PMID: 20133718

Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae. Shibata SB, Cortez SR, Beyer LA, Wiler JA, Di Polo A, Pfingst BE, Raphael Y. Exp Neurol. 2010, 223(2):464-72. PMID: 20109446

A neurotrophic rationale for the therapy of neurodegenerative disorders. Saragovi HU, Hamel E, Di Polo A. Curr Alzheimer Res. 2009, 6(5):419-23. PMID: 19874265

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. Lebrun-Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, Dickson K, Bowie D, Barker PA, Di Polo A. J Neurosci. 2009, 29(17):5536-45. PMID: 19403821

Inhibition of p75 (NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Lebrun-Julien F, Morquette B, Douillette A, Saragovi HU, Di Polo A. Mol Cell Neurosci. 2009, 40(4):410-20. PMID: 19146958

The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration. Yang C, Lafleur J, Mwaikambo BR, Zhu T, Gagnon C, Chemtob S, Di Polo A, Hardy P. Invest Ophthalmol Vis Sci. 2009, 50(3):1290-8. PMID: 18978343

Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE. J Neurosci. 2008, 28(43):11003-14. PMID: 18945908

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. Nat Med. 2008, 14(10):1067-76. PMID: 18836459

Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons. Chikar JA, Colesa DJ, Swiderski DL, Di Polo A, Raphael Y, Pfingst BE. Hear Res. 2008, 245(1-2):24-34. PMID: 18768155

Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma. Shi Z, Rudzinski M, Meerovitch K, Lebrun-Julien F, Birman E, Di Polo A, Saragovi HU. J Biol Chem. 2008, 283(43):29156-65. PMID: 18701465

Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? Morquette JB, Di Polo A. J Neuroophthalmol. 2008, 28(2):144-54. PMID: 18562848

Molecular and cell-based approaches for neuroprotection in glaucoma. Lebrun-Julien F, Di Polo A. Optom Vis Sci. 2008, 85(6):417-24. PMID: 18521011

A role for polyamines in retinal ganglion cell excitotoxic death. Pernet V, Bourgeois P, Di Polo A. J Neurochem. 2007, 103(4):1481-90. PMID: 17714450

Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Kwon BK, Liu J, Lam C, Plunet W, Oschipok LW, Hauswirth W, Di Polo A, Blesch A, Tetzlaff W. Spine. 2007, 32(11):1164-73. PMID: 17495772

Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF. Joly S, Pernet V, Chemtob S, Di Polo A, Lachapelle P. Invest Ophthalmol Vis Sci. 2007, 48(5):2311-20. PMID: 17460296

Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists. Bertrand J, Di Polo A, McKerracher L. Neurobiol Dis. 2007, 25(1):65-72. PMID: 17011202

Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2. Sapieha PS, Hauswirth WW, Di Polo A. J Neurosci Res. 2006, 83(6):985-95. PMID: 16493686

Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo. Pernet V, Di Polo A. Brain. 2006, 129(Pt 4):1014-26. PMID: 16418178

Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors. Gauthier R, Joly S, Pernet V, Lachapelle P, Di Polo A. Invest Ophthalmol Vis Sci. 2005, 46(9):3383-92. PMID: 16123443

Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma. Zhou Y, Pernet V, Hauswirth WW, Di Polo A. Mol Ther. 2005, 12(3):402-12. PMID: 15975850

Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Sapieha PS, Duplan L, Uetani N, Joly S, Tremblay ML, Kennedy TE, Di Polo A. Mol Cell Neurosci. 2005, 28(4):625-35. PMID: 15797710

Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo. Pernet V, Hauswirth WW, Di Polo A. J Neurochem. 2005, 93(1):72-83. PMID: 15773907

Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A. Mol Cell Neurosci. 2003, 24(3):656-72. PMID: 14664816

TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. Cheng L, Sapieha P, Kittlerova P, Hauswirth WW, Di Polo A. J Neurosci. 2002, 22(10):3977-86. PMID: 12019317

The human cGMP-PDE beta-subunit promoter region directs expression of the gene to mouse photoreceptors. Ogueta SB, Di Polo A, Flannery JG, Yamashita CK, Farber DB. Invest Ophthalmol Vis Sci. 2000, 41(13):4059-63. PMID: 11095595

Colocalization of TrkB and brain-derived neurotrophic factor proteins in green-red-sensitive cone outer segments. Di Polo A, Cheng L, Bray GM, Aguayo AJ. Invest Ophthalmol Vis Sci. 2000, 41(12):4014-21. PMID: 11053307

Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice. Gravel M, Di Polo A, Valera PB, Braun PE. J Neurosci Res. 1998, 53(4):393-404. PMID: 9710259

Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Di Polo A, Aigner LJ, Dunn RJ, Bray GM, Aguayo AJ. Proc Natl Acad Sci U S A. 1998, 95(7):3978-83. PMID: 9520478

Transcriptional activation of the human rod cGMP-phosphodiesterase beta-subunit gene is mediated by an upstream AP-1 element. Di Polo A, Lerner LE, Farber DB. Nucleic Acids Res. 1997, 25(19):3863-7. PMID: 9380509

Isolation and initial characterization of the 5′ flanking region of the human and murine cyclic guanosine monophosphate-phosphodiesterase beta-subunit genes. Di Polo A, Bowes Rickman C, Farber DB. Invest Ophthalmol Vis Sci. 1996, 37(4):551-60. PMID: 8595955

Rod photoreceptor-specific gene expression in human retinoblastoma cells. Di Polo A, Farber DB. Proc Natl Acad Sci U S A. 1995, 92(9):4016-20. PMID: 7732024