Publications

PEER-REVIEWED PUBLICATIONS – Dr. Adriana Di Polo PubMed Publications

PDFs of our publications are available upon request. Please send request to adriana.di.polo@umontreal.ca

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury. Morquette B, Morquette P, Agostinone J, Feinstein E, McKinney RA, Kolta A, Di Polo A. Cell Death Diff. 2014 [In Press]

Development of a Cell Permeable Competitive Antagonist of RhoA and CRMP4 binding, TAT-C4RIP, to Promote Neurite Outgrowth. Khazaei MR, Montcalm S, Di Polo A, Fournier AE, Durocher Y, Tone SO. J Mol Neurosci. 2014 [Epub ahead of print] PMID: 25015230

Drug and gene delivery to the back of the eye: from bench to bedside. Rowe-Rendleman CL, Durazo SA, Kompella UB, Rittenhouse KD, Di Polo A, Weiner AL, Grossniklaus HE, Naash MI, Lewin AS, Horsager A, Edelhauser HF. Invest Ophthalmol Vis Sci. 2014, 55(4):2714-2730. PMID: 24777644

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury. Wilson AM, Chiodo VA, Boye SL, Brecha NC, Hauswirth WW, Di Polo A. PLoS One. 2014, 9(4):e94175. PMID: 24714389

The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy. Slusar JE, Cairns EA, Szczesniak AM, Bradshaw HB, Di Polo A, Kelly ME. Neuropharmacology. 2013, 72:116-25. PMID: 23643752

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma. Almasieh M, MacIntyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Invest Ophthalmol Vis Sci. 2013, 54(5):3171-83. PMID: 23599333

ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. Wilson AM, Morquette B, Abdouh M, Unsain N, Barker PA, Feinstein E, Bernier G, Di Polo A. J Neurosci. 2013, 33(5):2205-16. PMID: 23365256

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice. Fukui H, Wong HT, Beyer LA, Case BG, Swiderski DL, Di Polo A, Ryan AF, Raphael Y. Sci Rep. 2012, 2:838. PMID: 23150788

The molecular basis of retinal ganglion cell death in glaucoma. Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. Prog Retin Eye Res. 2012, 31(2):152-81. PMID: 22155051

Gene therapy for retinal ganglion cell neuroprotection in glaucoma. Wilson AM, Di Polo A. Gene Ther. 2012, 19(2):127-36. PMID: 21975466

Current prospects in optic nerve protection and regeneration: sixth ARVO/Pfizer Ophthalmics Research Institute conference. Limb GA, Martin KR, Di Polo, A., et al. Sixth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Invest Ophthalmol Vis Sci. 2011, 52(8):5941-54. PMID: 21804096

A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1/2 pathway. Almasieh M, Lieven CJ, Levin LA, Di Polo A. J Neurochem. 2011, 118(6):1075-86. PMID: 21749374

Ocular neuroprotection by siRNA targeting caspase-2. Ahmed Z, Kalinski H, Berry M, Almasieh M, Ashush H, Slager N, Brafman A, Spivak I, Prasad N, Mett I, Shalom E, Alpert E, Di Polo A, Feinstein E, Logan A. Cell Death Dis. 2011, 2:e173. PMID: 21677688

Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Almasieh M, Zhou Y, Kelly ME, Casanova C, Di Polo A. Cell Death Dis. 2010, 1:e27. PMID: 21364635

ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, Di Polo A, Barker PA. Proc Natl Acad Sci U S A. 2010, 107(8):3817-22. PMID: 20133718

Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae. Shibata SB, Cortez SR, Beyer LA, Wiler JA, Di Polo A, Pfingst BE, Raphael Y. Exp Neurol. 2010, 223(2):464-72. PMID: 20109446

A neurotrophic rationale for the therapy of neurodegenerative disorders. Saragovi HU, Hamel E, Di Polo A. Curr Alzheimer Res. 2009, 6(5):419-23. PMID: 19874265

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. Lebrun-Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, Dickson K, Bowie D, Barker PA, Di Polo A. J Neurosci. 2009, 29(17):5536-45. PMID: 19403821

Inhibition of p75 (NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Lebrun-Julien F, Morquette B, Douillette A, Saragovi HU, Di Polo A. Mol Cell Neurosci. 2009, 40(4):410-20. PMID: 19146958

The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration. Yang C, Lafleur J, Mwaikambo BR, Zhu T, Gagnon C, Chemtob S, Di Polo A, Hardy P. Invest Ophthalmol Vis Sci. 2009, 50(3):1290-8. PMID: 18978343

Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE. J Neurosci. 2008, 28(43):11003-14. PMID: 18945908

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. Nat Med. 2008, 14(10):1067-76. PMID: 18836459

Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons. Chikar JA, Colesa DJ, Swiderski DL, Di Polo A, Raphael Y, Pfingst BE. Hear Res. 2008, 245(1-2):24-34. PMID: 18768155

Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma. Shi Z, Rudzinski M, Meerovitch K, Lebrun-Julien F, Birman E, Di Polo A, Saragovi HU. J Biol Chem. 2008, 283(43):29156-65. PMID: 18701465

Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? Morquette JB, Di Polo A. J Neuroophthalmol. 2008, 28(2):144-54. PMID: 18562848

Molecular and cell-based approaches for neuroprotection in glaucoma. Lebrun-Julien F, Di Polo A. Optom Vis Sci. 2008, 85(6):417-24. PMID: 18521011

A role for polyamines in retinal ganglion cell excitotoxic death. Pernet V, Bourgeois P, Di Polo A. J Neurochem. 2007, 103(4):1481-90. PMID: 17714450

Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Kwon BK, Liu J, Lam C, Plunet W, Oschipok LW, Hauswirth W, Di Polo A, Blesch A, Tetzlaff W. Spine. 2007, 32(11):1164-73. PMID: 17495772

Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF. Joly S, Pernet V, Chemtob S, Di Polo A, Lachapelle P. Invest Ophthalmol Vis Sci. 2007, 48(5):2311-20. PMID: 17460296

Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists. Bertrand J, Di Polo A, McKerracher L. Neurobiol Dis. 2007, 25(1):65-72. PMID: 17011202

Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2. Sapieha PS, Hauswirth WW, Di Polo A. J Neurosci Res. 2006, 83(6):985-95. PMID: 16493686

Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo. Pernet V, Di Polo A. Brain. 2006, 129(Pt 4):1014-26. PMID: 16418178

Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors. Gauthier R, Joly S, Pernet V, Lachapelle P, Di Polo A. Invest Ophthalmol Vis Sci. 2005, 46(9):3383-92. PMID: 16123443

Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma. Zhou Y, Pernet V, Hauswirth WW, Di Polo A. Mol Ther. 2005, 12(3):402-12. PMID: 15975850

Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Sapieha PS, Duplan L, Uetani N, Joly S, Tremblay ML, Kennedy TE, Di Polo A. Mol Cell Neurosci. 2005, 28(4):625-35. PMID: 15797710

Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo. Pernet V, Hauswirth WW, Di Polo A. J Neurochem. 2005, 93(1):72-83. PMID: 15773907

Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A. Mol Cell Neurosci. 2003, 24(3):656-72. PMID: 14664816

TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. Cheng L, Sapieha P, Kittlerova P, Hauswirth WW, Di Polo A. J Neurosci. 2002, 22(10):3977-86. PMID: 12019317

The human cGMP-PDE beta-subunit promoter region directs expression of the gene to mouse photoreceptors. Ogueta SB, Di Polo A, Flannery JG, Yamashita CK, Farber DB. Invest Ophthalmol Vis Sci. 2000, 41(13):4059-63. PMID: 11095595

Colocalization of TrkB and brain-derived neurotrophic factor proteins in green-red-sensitive cone outer segments. Di Polo A, Cheng L, Bray GM, Aguayo AJ. Invest Ophthalmol Vis Sci. 2000, 41(12):4014-21. PMID: 11053307

Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice. Gravel M, Di Polo A, Valera PB, Braun PE. J Neurosci Res. 1998, 53(4):393-404. PMID: 9710259

Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Di Polo A, Aigner LJ, Dunn RJ, Bray GM, Aguayo AJ. Proc Natl Acad Sci U S A. 1998, 95(7):3978-83. PMID: 9520478

Transcriptional activation of the human rod cGMP-phosphodiesterase beta-subunit gene is mediated by an upstream AP-1 element. Di Polo A, Lerner LE, Farber DB. Nucleic Acids Res. 1997, 25(19):3863-7. PMID: 9380509

Isolation and initial characterization of the 5′ flanking region of the human and murine cyclic guanosine monophosphate-phosphodiesterase beta-subunit genes. Di Polo A, Bowes Rickman C, Farber DB. Invest Ophthalmol Vis Sci. 1996, 37(4):551-60. PMID: 8595955

Rod photoreceptor-specific gene expression in human retinoblastoma cells. Di Polo A, Farber DB. Proc Natl Acad Sci U S A. 1995, 92(9):4016-20. PMID: 7732024